Cannabidiol efficiently suppressed the acquisition and expression of methamphetamine-induced conditioned place preference in the rat.

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. 2021 Feb 8;113158.

doi: 10.1016/j.bbr.2021.113158. Online ahead of print.

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Mahsa Anooshe et al. Behav Brain Res. .

Abstract

Methamphetamine (MET) is one of the most prevalently abused psychostimulants in the world with drastic repercussions. Several studies emphasized the inhibitory effect of Cannabidiol (CBD) on the reward properties of psychostimulants. The current investigation utilized conditioned place preference (CPP) to assay CBD’s impact on MET’s reward characteristic, including acquisition and expression phases of MET-induced CPP. Like our prior researches, animals received MET (1 mg/kg; sc) in a five-day schedule to induce CPP. The rats were given intracerebroventricular (ICV) microinjection of CBD (2, 10, and 50 µg/5 µl DMSO) during the 5-day conditioning phase in the CPP paradigm to highlight the CBD’s impact on the development (acquisition) of MET-induced place preference. Furthermore, animals were treated with CBD (2, 10 and 50 µg/5 µl) in the lateral ventricle on the post-conditioning day to elucidate the effect of ICV injection of CBD on the expression of MET-induced CPP. It was revealed that CBD (10 and 50 µg/5 µl) microinjection profoundly inhibited both phases of MET-induced CPP without any side effect on the locomotion in animals were treated by MET injection over conditioning phase. Also, CBD’s inhibitory impact was more potent in the acquisition phase than the expression phase of MET-induced CPP. Ultimately, the current research reported that CBD could be a beneficial compound to treat drug abuse however more investigations are needed.

Keywords: Acquisition; Cannabidiol; Conditioned place preference; Expression; Methamphetamine; Rat; Reward.

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