A Scoping Review on Clinical Trials of Pain Reduction With Cannabis Administration in Adults.

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Review

. 2020 Jun;12(6):344-351.

doi: 10.14740/jocmr4210. Epub 2020 Jun 4.

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Review

Reham Haleem et al. J Clin Med Res. .

Abstract

Indications of cannabis use are numerous although the indication to relief pain remains a major research interest and clinical application. Studies investigating the effect of herbal cannabis and cannabis-based medicine on neuropathic, non-neuropathic pain, acute pain and experimentally induced pain were reviewed. A search was performed in PubMed and Cochrane library for articles published in English between January 1, 2000 and May 8, 2020. The search terms used were related to cannabis and pain in adults. We identified 34 studies, of which 30 were randomized controlled clinical trials (RCTs). Varying effects were identified from the RCTs, and as expected more promising effects from non-RCTs. Cannabis-based medications were found most effective as an adjuvant therapy in refractory multiple sclerosis, and weak evidence was found to support the treatment of cancer pain especially in advanced stages. Chronic rheumatic pain showed promising results. Adverse events of cannabis-based treatment were found to be more frequent with tetrahydrocannabinol herbal strains compared to other cannabis-derived products.

Keywords: Cannabidiol; Cannabis; Dose; Pain; Safety.

Conflict of interest statement

None to declare.

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References

    1. Krcevski-Skvarc N, Wells C, Hauser W. Availability and approval of cannabis-based medicines for chronic pain management and palliative/supportive care in Europe: A survey of the status in the chapters of the European Pain Federation. Eur J Pain. 2018;22(3):440–454. doi: 10.1002/ejp.1147. – DOI PubMed
    1. Blake DR, Robson P, Ho M, Jubb RW, McCabe CS. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatology (Oxford) 2006;45(1):50–52. doi: 10.1093/rheumatology/kei183. – DOI PubMed
    1. Fine PG, Rosenfeld MJ. The endocannabinoid system, cannabinoids, and pain. Rambam Maimonides Med J. 2013;4(4):e0022. doi: 10.5041/RMMJ.10129. – DOI PMC PubMed
    1. Calignano A, La Rana G, Loubet-Lescoulie P, Piomelli D. A role for the endogenous cannabinoid system in the peripheral control of pain initiation. Prog Brain Res. 2000;129:471–482. doi: 10.1016/S0079-6123(00)29034-1. – DOI PubMed
    1. Guindon J, Hohmann AG. The endocannabinoid system and pain. CNS Neurol Disord Drug Targets. 2009;8(6):403–421. doi: 10.2174/187152709789824660. – DOI PMC PubMed

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