The present study shows the variability in chemical profiles of three different varieties of Cannabis sativa extracts used in medicinal cannabis oil when using two different extraction and evaporation methods. Procedures were compared by analyzing rate of total terpenoids to the principal cannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD), using gas chromatography coupled to mass spectrometry (GC-MS). The extraction of inflorescences using soxhlet method showed the highest mass of final extract. Also, the use of heating and the presence of oxygen when evaporating the solvents, greatly modified the final profiles due to evaporation or chemical reactions. These variations in chemical profiles must be carefully taken into account and standardized in the elaboration of medicinal oils.
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